Relationship Between MUC4 Variants and Metastatic Recurrence in Colorectal Cancer.

ABSTRACT:

Background

Recurrent metastasis after radical resection in patients of colorectal cancer (CRC) is a great challenge for the world, in which genomic alterations play a major role in tumorigenesis. MUC4 plays a significant role in recurrence and metastasis in tumor. This study is aimed at exploring the association between MUC4 variants and metastatic recurrence of CRC.

Methods

Forty-seven patients relapsing with metastasis and 37 patients remaining disease-free postoperatively were enrolled. Next-generation sequencing (NGS) detected mutations. Mutation and mRNA expression data were downloaded from TCGA and cBioPortal databases. We analyzed the relationship between MUC4 variants and clinical parameters, as well as possible molecular mechanisms.

Results

MUC4 variants rs56

SUBMITTER: Liu J 

PROVIDER: S-EPMC10629456 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature