Value of pneumococcal PCR in respiratory samples for exclusion of pneumococcal pneumonia.

ABSTRACT:

Background

Streptococcus pneumoniae is the main aetiological agent in bacterial pneumonia. Therefore pneumococcal PCR is often included in respiratory multiplex PCR panels, both commercial and in-house. But respiratory PCR results for S. pneumoniae are difficult to interpret due to frequent non-pathogenic colonization on the mucosal surface of the upper airways with pneumococci or to cross-reaction of the PCR target in non-pneumococcal streptococci. In this study we investigated the value of lytA gene pneumococcal PCR in patients presenting with pneumonia.

Objectives

To assess the utility of lytA gene detection for S. pneumoniae in a respiratory multiplex quantitative PCR (qPCR) panel for patients presenting with pneumonia.

Methods

A

SUBMITTER: Van Goethem S 

PROVIDER: S-EPMC10629468 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature