STREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology.

ABSTRACT: Triggering Receptor Expressed on Myeloid Cell 2 (TREM2) plays a crucial role in the transition of microglia from a state of homeostasis to a state associated with the disease. Mutations in TREM2 are strongly linked with a higher risk of developing neurodegenerative diseases, including Alzheimer's disease. There have been contradictory findings regarding the potential detrimental or protective effects of microglial activation and TREM2-related microglial responses in Alzheimer's disease. Although previous studies reported increased CSF soluble TREM2 (sTREM2) in different clinical stages of Alzheimer's disease, the exact association between Alzheimer's disease hallmarks such as amyloid-beta and tau pathology remains unclear. In the present study, I aimed to investigate the association betwee

SUBMITTER: Nabizadeh F 

PROVIDER: S-EPMC10629471 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature