Sex differences in socioemotional behavior and changes in ventral hippocampal transcription across aging in C57Bl/6J mice.

ABSTRACT: Socioemotional health is positively correlated with improved cognitive and physical aging. Despite known sex differences in socioemotional behaviors and the trajectory of aging, the interactive effects between sex and aging on socioemotional outcomes are poorly understood. We performed the most comprehensive assessment of sex differences in socioemotional behaviors in C57Bl/6J mice across aging to date. Compared to males, females exhibited decreased anxiety-like behavior and social preference but increased social recognition. With age, anxiety-like behavior, cued threat memory generalization, and social preference increased in both sexes. To investigate potential neural mechanisms underlying these behavioral changes, we analyzed transcriptional neuropathology markers in the ventral hippoca

SUBMITTER: Baumgartner NE 

PROVIDER: S-EPMC10629502 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature