Interconnections between m⁶A RNA modification, RNA structure, and protein-RNA complex assembly.

ABSTRACT: Protein-RNA complexes exist in many forms within the cell, from stable machines such as the ribosome to transient assemblies like the spliceosome. All protein-RNA assemblies rely on spatially and temporally coordinated interactions between specific proteins and RNAs to achieve a functional form. RNA folding and structure are often critical for successful protein binding and protein-RNA complex formation. RNA modifications change the chemical nature of a given RNA and often alter its folding kinetics. Both these alterations can affect how and if proteins or other RNAs can interact with the modified RNA and assemble into complexes. N⁶-methyladenosine (m⁶A) is the most common base modification on mRNAs and regulatory noncoding RNAs and has been shown to impact RNA struct

SUBMITTER: Hofler S 

PROVIDER: S-EPMC10629537 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature