A Longitudinal Study of Group A Streptococcal Colonization and Pharyngitis in US Children.

ABSTRACT:

Background

Group A streptococci (GAS) are a major cause of pharyngitis in children. Recently, there were severe GAS outbreaks. The aims of this study were to assess pharyngeal colonization prevalence in healthy children, to assess different diagnostic definitions for GAS pharyngitis and to estimate incidence rates for these infections.

Methods

A 2-year longitudinal study was conducted in healthy children in the United States. Pharyngeal swabs were cultured every 3 months for GAS colonization. Serum antistreptolysin O, antideoxyribonuclease B (DNaseB) and antistreptococcal C5a peptidase (SCP) antibody titers were assessed at baseline. When participants developed a sore throat, pharyngeal swabs were collected for rapid antigen detection test (RADT) and culture, and antibody ti

SUBMITTER: Frenck RW 

PROVIDER: S-EPMC10629608 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature