Serial laboratory biomarkers are associated with ICU outcomes in patients hospitalized with COVID-19.

ABSTRACT:

Background

Clinical utility of routinely measured serial biomarkers in predicting escalation of inpatient care intensity and mortality among hospitalized patients with COVID-19 remains unknown.

Methods

This retrospective cohort study included patients with COVID-19 who admitted to the Massachusetts General Hospital between March and June 2020 and January to March 2021. White blood cell (WBC) count, platelet count, C-reactive protein (CRP), and D-dimer values were measured on days 1, 3, and 7 of admission. Clinical outcomes include 30- and 60-day morality, ICU transfer, and overall survival (OS) over a follow-up period of 90 days. The association between serial biomarkers and outcomes were assessed using multivariable logistic regression and Cox proportional hazards models.

SUBMITTER: Wang X 

PROVIDER: S-EPMC10629639 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature