Theta-band phase locking during encoding leads to coordinated entorhinal-hippocampal replay.

ABSTRACT: Precisely timed interactions between hippocampal and cortical neurons during replay epochs are thought to support learning. Indeed, research has shown that replay is associated with heightened hippocampal-cortical synchrony. Yet many caveats remain in our understanding. Namely, it remains unclear how this offline synchrony comes about, whether it is specific to particular behavioral states, and how-if at all-it relates to learning. In this study, we sought to address these questions by analyzing coordination between CA1 cells and neurons of the deep layers of the medial entorhinal cortex (dMEC) while rats learned a novel spatial task. During movement, we found a subset of dMEC cells that were particularly locked to hippocampal LFP theta-band oscillations and that were preferentially coordi

SUBMITTER: Santos-Pata D 

PROVIDER: S-EPMC10629661 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature