Bayesian modeling of the impact of antibiotic resistance on the efficiency of MRSA decolonization.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality. Colonization by MRSA increases the risk of infection and transmission, underscoring the importance of decolonization efforts. However, success of these decolonization protocols varies, raising the possibility that some MRSA strains may be more persistent than others. Here, we studied how the persistence of MRSA colonization correlates with genomic presence of antibiotic resistance genes. Our analysis using a Bayesian mixed effects survival model found that genetic determinants of high-level resistance to mupirocin was strongly associated with failure of the decolonization protocol. However, we did not see a similar effect with genetic resistance to chlorhexidine or other antibiotics. Including s

SUBMITTER: Ojala F 

PROVIDER: S-EPMC10629663 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature