Mapping resistance-associated anthelmintic interactions in the model nematode Caenorhabditis elegans.

ABSTRACT: Parasitic nematodes infect billions of people and are mainly controlled by anthelmintic mass drug administration (MDA). While there are growing efforts to better understand mechanisms of anthelmintic resistance in human and animal populations, it is unclear how resistance mechanisms that alter susceptibility to one drug affect the interactions and efficacy of drugs used in combination. Mutations that alter drug permeability across primary nematode barriers have been identified as potential resistance mechanisms using the model nematode Caenorhabditis elegans. We leveraged high-throughput assays in this model system to measure altered anthelmintic susceptibility in response to genetic perturbations of potential cuticular, amphidial, and alimentary routes of drug entry. Mutations in genes as

SUBMITTER: Rehborg EG 

PROVIDER: S-EPMC10629664 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature