Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spatzle-processing enzyme CLIP2 in silkworm, Bombyx mori.

ABSTRACT: The Toll receptor signaling pathway is an important innate immune response of insects to pathogen infection; its extracellular signal transduction involves serine protease cascade activation. However, excessive or constitutive activation of the Toll pathway can be detrimental. Hence, the balance between activation and inhibition of the extracellular protease cascade must be tightly regulated to achieve favorable outcomes. Previous studies have shown that serpins-serine protease inhibitors-negatively regulate insect innate immunity by inhibiting extracellular protease cascade signaling. Although the roles of serpins in insect innate immunity are well described, the physiological mechanisms underlying their synergistic effects remain poorly understand. Here, we characterize the molecular mec

SUBMITTER: Liu H 

PROVIDER: S-EPMC10629668 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature