Atrophy in behavioural variant frontotemporal dementia spans multiple large-scale prefrontal and temporal networks.

ABSTRACT: The identification of a neurodegenerative disorder's distributed pattern of atrophy-or atrophy 'signature'-can lend insights into the cortical networks that degenerate in individuals with specific constellations of symptoms. In addition, this signature can be used as a biomarker to support early diagnoses and to potentially reveal pathological changes associated with said disorder. Here, we characterized the cortical atrophy signature of behavioural variant frontotemporal dementia (bvFTD). We used a data-driven approach to estimate cortical thickness using surface-based analyses in two independent, sporadic bvFTD samples (n = 30 and n = 71, total n = 101), using age- and gender-matched cognitively and behaviourally normal individuals. We found highly similar patterns of cortical atrophy ac

SUBMITTER: Eldaief MC 

PROVIDER: S-EPMC10629759 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature