Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions.

ABSTRACT: Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of Parkinson's disease and other neurological and psychiatric disorders. Electrodes are chronically implanted in disease-relevant brain regions and pulsatile electrical stimulation delivery is intended to restore neurocircuit function. However, the widespread interest in the application and expansion of this clinical therapy has preceded an overarching understanding of the neurocircuit alterations invoked by deep brain stimulation. Over the years, various forms of neurophysiological evidence have emerged which demonstrate changes to brain activity across spatiotemporal resolutions; from single neuron, to local field potential, to brain-wide cortical network effects. Though fruitful, such studies have often led

SUBMITTER: Neumann WJ 

PROVIDER: S-EPMC10629774 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature