Identification of new candidate drugs for primary Sjogren's syndrome using a drug repurposing transcriptomic approach.

ABSTRACT:

Objectives

To date, no immunomodulatory drug has demonstrated its efficacy in primary SS (pSS). We sought to analyse potential commonalities between pSS transcriptomic signatures and signatures of various drugs or specific knock-in or knock-down genes.

Methods

Gene expression from peripheral blood samples of patients with pSS was compared with that of healthy controls in two cohorts and three public databases. In each of the five datasets, we analysed the 150 most up- and downregulated genes between pSS patients and controls with regard to the differentially expressed genes resulting from the biological action on nine cell lines of 2837 drugs, 2160 knock-in and 3799 knock-down genes in the Connectivity Map database.

Results

We analysed 1008 peripheral blood transcript

SUBMITTER: Felten R 

PROVIDER: S-EPMC10629788 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature