Regional cortical thinning, demyelination and iron loss in cerebral small vessel disease.

ABSTRACT: The link between white matter hyperintensities (WMH) and cortical thinning is thought to be an important pathway by which WMH contributes to cognitive deficits in cerebral small vessel disease (SVD). However, the mechanism behind this association and the underlying tissue composition abnormalities are unclear. The objective of this study is to determine the association between WMH and cortical thickness, and the in vivo tissue composition abnormalities in the WMH-connected cortical regions. In this cross-sectional study, we included 213 participants with SVD who underwent standardized protocol including multimodal neuroimaging scans and cognitive assessment (i.e. processing speed, executive function and memory). We identified the cortex connected to WMH using probabilistic tractography sta

SUBMITTER: Li H 

PROVIDER: S-EPMC10629800 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature