Initial feasibility and challenges of hyperpolarized ¹²⁹ Xe MRI in neonates with bronchopulmonary dysplasia.

ABSTRACT:

Purpose

The underlying functional and microstructural lung disease in neonates who are born preterm (bronchopulmonary dysplasia, BPD) remains poorly characterized. Moreover, there is a lack of suitable techniques to reliably assess lung function in this population. Here, we report our preliminary experience with hyperpolarized ¹²⁹ Xe MRI in neonates with BPD.

Methods

Neonatal intensive care patients with established BPD were recruited (N = 9) and imaged at a corrected gestational age of median:40.7 (range:37.1, 44.4) wk using a 1.5T neonatal scanner. 2D ¹²⁹ Xe ventilation and diffusion-weighted images and dissolved phase spectroscopy were acquired, alongside ¹ H 3D radial UTE. ¹²⁹ Xe images were acquired during a series of short ap

SUBMITTER: Stewart NJ 

PROVIDER: S-EPMC10629838 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature