Assessment of Safety Profile of Activated Curcumin C3 Complex (AC³®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa.

ABSTRACT: The present work was carried out to investigate the toxic effects of Activated Curcumin C3 Complex (AC³®) through the methods of acute, subacute, subchronic, reproductive/developmental toxicity, and genotoxicity when administered orally in experimental rodents. The studies were carried out in line with OECD principles of good laboratory practice. A single-dose acute oral toxicity study was conducted on female Wistar rats that produced no toxic effects after 14 days (the observation period) of treatment. Subacute, subchronic, and reproductive/developmental studies were conducted in Wistar rats, divided equally into vehicle control, 125, 250, and 500 mg/kg dose groups along with recovery groups for vehicle control and high dose. In all the studies, there were no abnormal clinical

SUBMITTER: Majeed M 

PROVIDER: S-EPMC10629997 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature