Prediction of pulmonary aspergillosis in patients with ventilator-associated pneumonia.

ABSTRACT:

Background

Predictors of ICU-acquired pulmonary aspergillosis (IPA) are not well-established in critically ill patients with ventilator-associated pneumonia (VAP), making IPA commonly misdiagnosed and anti-fungal therapy delayed. We aimed to develop a clinical score for prediction of IPA among patients with VAP.

Methods

Mechanically ventilated patients who developed VAP in 4 ICUs in Bretagne, Western France, were included. The score was constructed in a learning cohort, based on predictors of IPA in logistic regression model, and validated in a validation cohort.

Results

Among 1636 mechanically ventilated patients, 215 developed VAP but only 39 developed IPA (4 possible and 35 probable/putative) (18%). Most cases (31/39) were documented through a positive broncho-alve

SUBMITTER: Massart N 

PROVIDER: S-EPMC10630265 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature