Diversity and evolution of the MHC class II DRB gene in the Capra sibirica experienced a demographic fluctuation in China.

ABSTRACT: The major histocompatibility complex (MHC) genes are the most polymorphic genes in vertebrates, and their proteins play a critical role in adaptive immunity for defense against a variety of pathogens. MHC diversity was lost in many species after experiencing a decline in size. To understand the variation and evolution of MHC genes in the Siberian ibex, Capra sibirica, which has undergone a population decline, we analyzed the variation of the second exon of MHC class II DRB genes in samples collected from five geographic localities in Xinjiang, China, that belong to three diverged mitochondrial clades. Consequently, we identified a total of 26 putative functional alleles (PFAs) with 260 bp in length from 43 individuals, and found one (for 27 individuals) to three (for 5 individuals) PFAs pe

SUBMITTER: Dong PP 

PROVIDER: S-EPMC10630338 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature