Ptychographic lens-less birefringence microscopy using a mask-modulated polarization image sensor.

ABSTRACT: Birefringence, an inherent characteristic of optically anisotropic materials, is widely utilized in various imaging applications ranging from material characterizations to clinical diagnosis. Polarized light microscopy enables high-resolution, high-contrast imaging of optically anisotropic specimens, but it is associated with mechanical rotations of polarizer/analyzer and relatively complex optical designs. Here, we present a form of lens-less polarization-sensitive microscopy capable of complex and birefringence imaging of transparent objects without an optical lens and any moving parts. Our method exploits an optical mask-modulated polarization image sensor and single-input-state LED illumination design to obtain complex and birefringence images of the object via ptychographic phase retr

SUBMITTER: Kim J 

PROVIDER: S-EPMC10630341 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature