OncoCTMiner: streamlining precision oncology trial matching via molecular profile analysis.

ABSTRACT: By establishing omics sequencing of patient tumors as a crucial element in cancer treatment, the extensive implementation of precision oncology necessitates effective and prompt execution of clinical studies for approving molecular-targeted therapies. However, the substantial volume of patient sequencing data, combined with strict clinical trial criteria, increasingly complicates the process of matching patients to precision oncology studies. To streamline enrollment in these studies, we developed OncoCTMiner, an automated pre-screening platform for molecular cancer clinical trials. Through manual tagging of eligibility criteria for 2227 oncology trials, we identified key bio-concepts such as cancer types, genes, alterations, drugs, biomarkers and therapies. Utilizing this manually annotat

SUBMITTER: Xu Q 

PROVIDER: S-EPMC10630409 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature