Unappreciated subcontinental admixture in Europeans and European Americans and implications for genetic epidemiology studies.

ABSTRACT: European-ancestry populations are recognized as stratified but not as admixed, implying that residual confounding by locus-specific ancestry can affect studies of association, polygenic adaptation, and polygenic risk scores. We integrate individual-level genome-wide data from ~19,000 European-ancestry individuals across 79 European populations and five European American cohorts. We generate a new reference panel that captures ancestral diversity missed by both the 1000 Genomes and Human Genome Diversity Projects. Both Europeans and European Americans are admixed at the subcontinental level, with admixture dates differing among subgroups of European Americans. After adjustment for both genome-wide and locus-specific ancestry, associations between a highly differentiated variant in LCT (rs49

SUBMITTER: Gouveia MH 

PROVIDER: S-EPMC10630423 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature