Bioinformatics analyses of potentially common pathogenic networks for primary Sjogren's syndrome complicated with acute myocardial infarction.

ABSTRACT: Both primary Sjögren's syndrome (pSS) and acute myocardial infarction (AMI) are intricately linked. However, their common mechanism is not fully understood. Herein, we examined the underlying network of molecular action associated with developing this complication. Datasets were downloaded from the GEO database. We performed enrichment and protein-protein interaction analyses and screened key genes. We used external datasets to confirm the diagnostic performance for these hub genes. Transcription factor and microRNA regulatory networks were constructed for the validated hub genes. Finally, drug prediction and molecular docking validation were performed. We identified 62 common DEGs, many of which were enriched regarding inflammation and immune response. 5 DEGs were found as key hub genes (

SUBMITTER: Hou Q 

PROVIDER: S-EPMC10630427 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature