Association of elevated levels of peripheral complement components with cortical thinning and impaired logical memory in drug-naive patients with first-episode schizophrenia.

ABSTRACT: Schizophrenia has been linked to polymorphism in genes encoding components of the complement system, and hyperactive complement activity has been linked to immune dysfunction in schizophrenia patients. Whether and how specific complement components influence brain structure and cognition in the disease is unclear. Here we compared 52 drug-naïve patients with first-episode schizophrenia and 52 healthy controls in terms of levels of peripheral complement factors, cortical thickness (CT), logical memory and psychotic symptoms. We also explored the relationship between complement factors with CT, cognition and psychotic symptoms. Patients showed significantly higher levels of C1q, C4, factor B, factor H, and properdin in plasma. Among patients, higher levels of C3 in plasma were associated wit

SUBMITTER: Yu H 

PROVIDER: S-EPMC10630449 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature