Redox-responsive peptide-based complex coacervates as delivery vehicles with controlled release of proteinous drugs.

ABSTRACT: Proteinous drugs are highly promising therapeutics to treat various diseases. However, they suffer from limited circulation times and severe off-target side effects. Inspired by active membraneless organelles capable of dynamic recruitment and releasing of specific proteins, here, we present the design of coacervates as therapeutic protocells, made from small metabolites (anionic molecules) and simple arginine-rich peptides (cationic motif) through liquid-liquid phase separation. These complex coacervates demonstrate that their assembly and disassembly can be regulated by redox chemistry, which helps to control the release of the therapeutic protein. A model proteinous drugs, tissue plasminogen activator (tPA), can rapidly compartmentalize inside the complex coacervates, and the coacervate

SUBMITTER: Wang J 

PROVIDER: S-EPMC10630460 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature