Sex-specific risk factors associated with graves' orbitopathy in Korean patients with newly diagnosed graves' disease.

ABSTRACT:

Objective

To assess sex-specific risk factors for Graves' orbitopathy (GO) in newly diagnosed Graves' disease (GD) patients.

Methods

A retrospective cohort study was conducted using the National Health Insurance Service's sample database, which consisted of 1,137,861 subjects from 2002 to 2019. The international classification of disease-10 codes was used to identify those who developed GD (E05) and GO (H062). A multivariable Cox proportional hazards model was used to estimate the effect of risk factors on GO development.

Results

Among 2145 male and 5047 female GD patients, GO occurred in 134 men (6.2%) and 293 women (5.8%). A multivariable Cox regression model revealed that GO development was significantly associated with younger age (HR = 0.84, 95% CI = 0.73-0.98),

SUBMITTER: Lee J 

PROVIDER: S-EPMC10630462 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature