Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration.

ABSTRACT: Organ regeneration necessitates precise coordination of accelerators and brakes to restore organ function. However, the mechanisms underlying this intricate molecular crosstalk remain elusive. In this study, the level of proenkephalin-A (PENK-A), expressed by renal proximal tubular epithelial cells, decreases significantly with the loss of renal proximal tubules and increased at the termination phase of zebrafish kidney regeneration. Notably, this change contrasts with the role of hydrogen peroxide (H₂O₂), which acts as an accelerator in kidney regeneration. Through experiments with penka mutants and pharmaceutical treatments, we demonstrate that PENK-A inhibits H₂O₂ production in a dose-dependent manner, suggesting its involvement in regulating

SUBMITTER: Liu C 

PROVIDER: S-EPMC10630464 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature