The Severity of Reduced Esophageal Distensibility Parallels Eosinophilic Esophagitis Disease Duration.

ABSTRACT:

Background & aims

Chronic inflammation of eosinophilic esophagitis (EoE) results in progressive, fibrostenotic remodeling of the esophageal wall. This study aimed to demonstrate objective changes in esophageal distensibility relative to duration of EoE disease using a functional lumen imaging probe (FLIP).

Methods

Adult patients with EoE who completed a 16-cm FLIP protocol during endoscopy were evaluated in a cross-sectional study. FLIP analysis focused on distensibility plateau (DP) of the esophageal body. The time from onset of symptoms to time of endoscopy with FLIP was assessed, as was time from symptom onset to EoE diagnosis (ie, diagnostic delay).

Results

A total of 171 patients (mean age 38 ± 12 years; 31% female) were included; the median symptom duration was

SUBMITTER: Araujo IK 

PROVIDER: S-EPMC10630533 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature