Invariant natural killer T cells and incidence of first-time coronary events: a nested case-control study.

ABSTRACT:

Aims

Invariant natural killer T (iNKT) cells, a T cell subset that is CD1d-restricted and expresses a semi-invariant T cell receptor, have been proposed to contribute to dyslipidaemia-driven cardiovascular disease due to their ability to specifically recognize lipid antigens. Studies in mice have attributed pro-atherogenic properties to iNKT cells, but studies in humans investigating associations of iNKT cells with incident coronary events (CE) are lacking.

Methods and results

Here, we used flow cytometry to enumerate circulating iNKT cells (CD3⁺ CD1d-PBS57-Tetramer⁺) in a case-control cohort nested within the prospective population-based Malmö Diet and Cancer Study (n = 416) to explore associations with incident first-time CE during a median fol

SUBMITTER: Tomas L 

PROVIDER: S-EPMC10630548 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature