The prognostic impact of SIGLEC5-induced impairment of CD8⁺ T cell activation in sepsis.

ABSTRACT:

Background

Sepsis is associated with T-cell exhaustion, which significantly reduces patient outcomes. Therefore, targeting of immune checkpoints (ICs) is deemed necessary for effective sepsis management. Here, we evaluated the role of SIGLEC5 as an IC ligand and explored its potential as a biomarker for sepsis.

Methods

In vitro and in vivo assays were conducted to both analyse SIGLEC5's role as an IC ligand, as well as assess its impact on survival in sepsis. A multicentre prospective cohort study was conducted to evaluate the plasmatic soluble SIGLEC5 (sSIGLEC5) as a mortality predictor in the first 60 days after admission in sepsis patients. Recruitment included sepsis patients (n = 346), controls with systemic inflammatory response syndrome (n = 80), aneurism (n = 11), st

SUBMITTER: Lozano-Rodriguez R 

PROVIDER: S-EPMC10630607 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature