Plasma metabolomic profiling of patients with transient ischemic attack reveals positive role of neutrophils in ischemic tolerance.

ABSTRACT:

Background

Transient ischemic attack (TIA) induces ischemic tolerance that can reduce the subsequent ischemic damage and improve prognosis of patients with stroke. However, the underlying mechanisms remain elusive. Recent advances in plasma metabolomics analysis have made it a powerful tool to investigate human pathophysiological phenotypes and mechanisms of diseases. In this study, we aimed to identify the bioactive metabolites from the plasma of patients with TIA for determination of their prophylactic and therapeutic effects on protection against cerebral ischemic stroke, and the mechanism of TIA-induced ischemic tolerance against subsequent stroke.

Methods

Metabolomic profiling using liquid chromatography-mass spectrometry was performed to identify the TIA-induced differ

SUBMITTER: Liu R 

PROVIDER: S-EPMC10630611 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature