Overactivation of GnRH neurons is sufficient to trigger polycystic ovary syndrome-like traits in female mice.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder leading to anovulatory infertility. Abnormalities in the central neuroendocrine system governed by gonadotropin-releasing hormone (GnRH) neurons might be related to ovarian dysfunction in PCOS, although the link in this disordered brain-to-ovary communication remains unclear. Here, we manipulated GnRH neurons using chemogenetics in adult female mice to unveil whether chronic overaction of these neurons would trigger PCOS-like hormonal and reproductive impairments.

Methods

We used adult Gnrh1^cre female mice to selectively target and express the designer receptors exclusively activated by designer drugs (DREADD)-based chemogenetic tool hM3D(Gq) in hypophysiotropic GnRH neurons. Chronic

SUBMITTER: Silva MSB 

PROVIDER: S-EPMC10630624 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature