Using Goldmann Visual Field Volume to Track Disease Progression in Choroideremia.

ABSTRACT:

Purpose

Choroideremia is an X-linked choroidopathy caused by pathogenic variants in the CHM gene. It is characterized by the early appearance of multiple scotomas in the peripheral visual field that spread and coalesce, usually sparing central vision until late in the disease. These features make quantitative monitoring of visual decline particularly challenging. Here, we describe a novel computational approach to convert Goldmann visual field (GVF) data into quantitative volumetric measurements. With this approach, we analyzed visual field loss in a longitudinal, retrospective cohort of patients with choroideremia.

Design

Single-center, retrospective, cohort study.

Participants

We analyzed data from 238 clinic visits of 56 molecularly-confirmed male patients w

SUBMITTER: DeLuca AP 

PROVIDER: S-EPMC10630671 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature