Estimated Ovulatory Years Prior to Menopause and Postmenopausal Endogenous Hormone Levels.

ABSTRACT:

Background

Lifetime ovulatory years (LOY) is estimated by the difference between ages at menopause and menarche subtracting time for events interrupting ovulation. We tested whether LOY influences sex hormone levels in postmenopausal women with at least one intact ovary not using hormones.

Methods

Estradiol, estrone, estrone sulfate, total testosterone, dehydroepiandrostendione sulfate, prolactin, and sex hormone binding globulin were measured in 1,976 postmenopausal women from the Nurses' Health Study. Associations of age, body mass index (BMI), smoking, alcohol use, and other factors on hormones were assessed by t tests and ANOVA. Linear regression was used to assess multivariable adjusted associations between LOY and hormones and trends in hormone levels per 5-year increa

SUBMITTER: Cramer DW 

PROVIDER: S-EPMC10630892 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature