Development of Robust Cationic Light-Activated Thermosensitive Liposomes: Choosing the Right Lipids.

ABSTRACT: Extensive research has been conducted on cationic light-activated thermosensitive liposomes (CLTSLs) as a means for site-specific and controlled drug release; however, less attention has been given to the stability of these nanoparticles. Selecting the appropriate lipids is crucial for the development of a stable and responsive system. In this study, we investigated the impact of various lipids on the physical properties of cationic light-activated liposomes. Incorporating poly(ethylene glycol) PEG molecules resulted in uniform liposomes with low polydispersity index, while the addition of unsaturated lipid (DOTAP) resulted in extremely leaky liposomes, with almost 80% release in just 10 min of incubation at body temperature. Conversely, the inclusion of cholesterol in the formulation incr

SUBMITTER: Gangurde P 

PROVIDER: S-EPMC10630945 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature