Efficient Drug Loading Method for Poorly Water-Soluble Drug into Bicelles through Passive Diffusion.

ABSTRACT: The bicelle, a type of solid lipid nanoparticle, comprises phospholipids with varying alkyl chain lengths and possesses the ability to solubilize poorly water-soluble drugs. Bicelle preparation is complicated and time-consuming because conventional drug-loading methods in bicelles require multiple rounds of thermal cycling or co-grinding with drugs and lipids. In this study, we proposed a simple drug-loading method for bicelles that utilizes passive diffusion. Drug-unloaded bicelles were placed inside a dialysis device and incubated in a saturated solution of ketoconazole (KTZ), which is a model drug. KTZ was successfully loaded into bare bicelles over time with morphological changes, and the final encapsulated concentration was dependent on the lipid concentration of the bicelles. When po

SUBMITTER: Arai Y 

PROVIDER: S-EPMC10630946 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature