VBCG: 20 validated bacterial core genes for phylogenomic analysis with high fidelity and resolution.

ABSTRACT:

Background

Phylogenomic analysis has become an inseparable part of studies of bacterial diversity and evolution, and many different bacterial core genes have been collated and used for phylogenomic tree reconstruction. However, these genes have been selected based on their presence and single-copy ratio in all bacterial genomes, leaving out the gene's 'phylogenetic fidelity' unexamined.

Results

From 30,522 complete genomes covering 11,262 species, we examined 148 bacterial core genes that have been previously used for phylogenomic analysis. In addition to the gene presence and single-copy rations, we evaluated the gene's phylogenetic fidelity by comparing each gene's phylogeny with its corresponding 16S rRNA gene tree. Out of the 148 bacterial genes, 20 validated bacterial c

SUBMITTER: Tian R 

PROVIDER: S-EPMC10631056 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature