Identifying major depressive disorder with associated sleep disturbances through fMRI regional homogeneity at rest.

ABSTRACT:

Background

Anomalies in regional homogeneity (ReHo) have been documented in patients with major depressive disorder (MDD) and sleep disturbances (SDs). This investigation aimed to scrutinize changes in ReHo in MDD patients with comorbid SD, and to devise potential diagnostic biomarkers for detecting sleep-related conditions in patients with MDD.

Methods

Patients with MDD and healthy controls underwent resting-state functional magnetic resonance imaging scans. SD severity was quantified using the 17-item Hamilton Rating Scale for Depression. Subsequent to the acquisition of imaging data, ReHo analysis was performed, and a support vector machine (SVM) method was employed to assess the utility of ReHo in discriminating MDD patients with SD.

Results

Compared with MDD pati

SUBMITTER: Lv D 

PROVIDER: S-EPMC10631123 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature