Multimeric immunotherapeutic complexes activating natural killer cells towards HIV-1 cure.

ABSTRACT:

Background

Combination antiretroviral therapy (cART) has dramatically extended the life expectancy of people living with HIV-1 and improved their quality of life. There is nevertheless no cure for HIV-1 infection since HIV-1 persists in viral reservoirs of latently infected CD4⁺ T cells. cART does not eradicate HIV-1 reservoirs or restore cytotoxic natural killer (NK) cells which are dramatically reduced by HIV-1 infection, and express the checkpoint inhibitors NKG2A or KIR2DL upregulated after HIV-1 infection. Cytotoxic NK cells expressing the homing receptor CXCR5 were recently described as key subsets controlling viral replication.

Methods

We designed and evaluated the potency of "Natural killer activating Multimeric immunotherapeutic compleXes", called as NaMi

SUBMITTER: Schober R 

PROVIDER: S-EPMC10631209 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature