Infectious outcomes of fibrin sheath disruption in tunneled dialysis catheters.

ABSTRACT:

Background and objectives

Fibrin sheath (FS) formation around tunneled central venous catheters (CVC) increases the risk of catheter-related bloodstream infections due to bacterial adherence to a biofilm. We sought to investigate whether FS disruption (FSD) at the time of CVC removal or exchange affects infectious outcomes in patients with CVC-related infections.

Design, setting, participants, and measurements

Retrospective cohort study of 307 adult maintenance hemodialysis patients aged 18 years or older at a single center academic-based hemodialysis program (UHN, Toronto) who developed CVC-related infections requiring CVC removal or exchange between January 2000 and January 2019. Exposure was FSD at the time of CVC removal or exchange. Outcomes were infectious metastatic c

SUBMITTER: Waters M 

PROVIDER: S-EPMC10631277 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature