Identifying the white matter pathways involved in multiple sclerosis-related tremor using diffusion tensor imaging.

ABSTRACT:

Background

Tremor affects up to 45% of patients with Multiple Sclerosis (PwMS). Current understanding is based on insights from other neurological disorders, thus, not fully addressing the distinctive aspects of MS pathology.

Objective

To characterize the brain white matter (WM) correlates of MS-related tremor using diffusion tensor imaging (DTI).

Methods

In a prospective case-control study, PwMS with tremor were assessed for tremor severity and underwent MRI scans including DTI. PwMS without tremor served as matched controls. After tract selection and segmentation, the resulting diffusivity measures were used to calculate group differences and correlations with tremor severity.

Results

This study included 72 PwMS. The tremor group (n = 36) exhibited significan

SUBMITTER: Bayoumi A 

PROVIDER: S-EPMC10631316 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature