Optimizing statin therapy for primary prevention of cardiovascular disease in type 2 diabetes mellitus patients: Exploring dose, class, and intensity.

ABSTRACT:

Purpose

To investigate the impact of statin use on primary prevention of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM) in a dose-, class-, and use intensity-dependent manner.

Methods

We used an inverse probability treatment-weighted Cox hazards model, with statin use status as a time-dependent variable.

Results

Our results showed that statin use was associated with a significant reduction in CVD risk with an adjusted hazard ratio of 0.39. Pitavastatin was found to have the lowest CVD risk among the different classes of statins, followed by rosuvastatin, pravastatin, atorvastatin, simvastatin, fluvastatin, and lovastatin. Our analysis also revealed that a higher cumulative defined daily dose per year of statin was associated with a lower

SUBMITTER: Yu JM 

PROVIDER: S-EPMC10631324 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature