Deiodinase Type 3 Polymorphism (rs1190716) Affects Therapeutic Response to Levothyroxine.

ABSTRACT:

Objectives

Levothyroxine (LT4) is a commonly used treatment for hypothyroidism. Deiodinase enzymes control the metabolism and homeostasis of thyroid hormones (THs). Deiodinase type 3 gene (DIO3) encodes deiodinase type 3 enzyme (D3), and the genetic polymorphisms of this gene could affect the levels of THs and the response to LT4 treatment. This study aimed to investigate the single-nucleotide polymorphism (SNP), rs1190716; C > T, of DIO3 as a candidate genetic variant that might affect the clinical response to LT4 treatment.

Materials and methods

Two hundred Iraqi hypothyroid female patients aged 40 years were enrolled in this cross-sectional study. All of them were already on the LT4 treatment for at least 4 months. THs [thyroxin (T4), triiodothyronine (T3), reverse triiod

SUBMITTER: Mohmmed AH 

PROVIDER: S-EPMC10631360 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature