Highly sensitive detection of circulating tumour cells based on an ASV/CV dual-signal electrochemical strategy.

ABSTRACT: Circulating tumour cells (CTCs), as a tumour marker, may provide more information in early diagnosis and accurate therapy of cancer patients. Electrochemical detection of CTCs has exhibited exceptional advantages. However, single-signal electrochemical detection usually has a high probability of false positives coming from interferents, operating personnel, and nonstandard analytical processes. Herein, a dual-signal strategy using anodic stripping voltammetry (ASV) and cyclic voltammetry (CV) for highly sensitive detection of CTCs was developed. When MCF-7 cells were present, aptamer DNA (DNA1)-magnetic beads (MBs) were captured by CTCs and detached from the biosensing electrodes. Following magnetic separation, polystyrene bead (PS)-CdS QDs labelled on MCF-7 cells were dissolved by HNO

SUBMITTER: Wang G 

PROVIDER: S-EPMC10631473 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature