Interactions of Indoleamine 2,3-dioxygenase-expressing LAMP3⁺ dendritic cells with CD4⁺ regulatory T cells and CD8⁺ exhausted T cells: synergistically remodeling of the immunosuppressive microenvironment in cervical cancer and therapeutic implications.

ABSTRACT:

Background

Cervical cancer (CC) is the fourth most common cancer in women worldwide. Although immunotherapy has been applied in clinical practice, its therapeutic efficacy remains far from satisfactory, necessitating further investigation of the mechanism of CC immune remodeling and exploration of novel treatment targets. This study aimed to investigate the mechanism of CC immune remodeling and explore potential therapeutic targets.

Methods

We conducted single-cell RNA sequencing on a total of 17 clinical specimens, including normal cervical tissues, high-grade squamous intraepithelial lesions, and CC tissues. To validate our findings, we conducted multicolor immunohistochemical staining of CC tissues and constructed a subcutaneous tumorigenesis model in C57BL/6 mice using m

SUBMITTER: Qu X 

PROVIDER: S-EPMC10631485 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature