Comparative and mechanistic toxicity assessment of structure-dependent toxicity of carbon-based nanomaterials.

ABSTRACT: The wide application of carbon-based nanomaterials (CNMs) has resulted in the ubiquity of CNMs in the natural environment and they potentially impose adverse consequences on ecosystems and human health. In this study, we comprehensively evaluated and compared potential toxicological effects and mechanisms of seven CNMs in three representative types (carbon blacks, graphene nanoplatelets, and fullerenes), to elucidate the correlation between their physicochemical/structural properties and toxicity. We employed a recently-developed quantitative toxicogenomics-based toxicity testing system with GFP-fused yeast reporter library targeting main cellular stress response pathways, as well as conventional phenotype-based bioassays. The results revealed that DNA damage, oxidative stress, and protein

SUBMITTER: Jiang T 

PROVIDER: S-EPMC10631494 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature