Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.

ABSTRACT:

Background

Cardiac ventricles provide the contractile force of the beating heart throughout life. How the primitive endocardium-layered myocardial projections called trabeculae form and mature into the adult ventricles is of great interest for biology and regenerative medicine. Trabeculation is dependent on the signaling protein Nrg1 (neuregulin-1). However, the mechanism of action of Nrg1 and its role in ventricular wall maturation are poorly understood.

Methods

We investigated the functions and downstream mechanisms of Nrg1 signaling during ventricular chamber development using confocal imaging, transcriptomics, and biochemical approaches in mice with cardiac-specific inactivation or overexpression of Nrg1.

Results

Analysis of cardiac-specific Nrg1 mutant mic

SUBMITTER: Grego-Bessa J 

PROVIDER: S-EPMC10631509 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature