Ontology highlight
ABSTRACT:
SUBMITTER: Saxena K
PROVIDER: S-EPMC10631552 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Saxena Kritika K Roverato Nicola Domenico ND Reithmann Melody M Mah Mei Min MM Schregle Richard R Schmidtke Gunter G Silbern Ivan I Urlaub Henning H Aichem Annette A
Life science alliance 20231108 1
IFN-I secretion provides a rapid host defense against infection with RNA viruses. Within the host cell, viral RNA triggers the activation of the RIG-I signaling pathway, leading to the production of IFN-I. Because an exaggerated IFN-I response causes severe tissue damage, RIG-I signaling is tightly regulated. One of the factors that control the IFN-I response is the ubiquitin-like modifier FAT10, which is induced by TNF and IFNγ and targets covalently FAT10-linked proteins for proteasomal degrad ...[more]