Evaluation of Free Valproate Concentration in Critically Ill Patients.

ABSTRACT: Protein binding of valproate is variable in ICU patients, and the total valproate concentration does not predict the free valproate concentration, even when correcting for albumin. We sought to quantify valproate free concentration among ICU patients, identify risk factors associated with an increasing free valproate concentration, and evaluate the association between free valproate concentration with potential adverse drug effect.

Design

Retrospective multicenter cohort study.

Setting

Two academic medical centers.

Patients

Patients greater than or equal to 18 years of age with concomitant free and total valproate concentrations collected in the ICU.

Interventions

None.

Measurements and main results

Two-hundred fifty-six patients were included in the stud

SUBMITTER: Brown CS 

PROVIDER: S-EPMC10631734 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature