A mechanistic insight into sources of error of visual working memory in multiple sclerosis.

ABSTRACT: Working memory (WM) is one of the most affected cognitive domains in multiple sclerosis (MS), which is mainly studied by the previously established binary model for information storage (slot model). However, recent observations based on the continuous reproduction paradigms have shown that assuming dynamic allocation of WM resources (resource model) instead of the binary hypothesis will give more accurate predictions in WM assessment. Moreover, continuous reproduction paradigms allow for assessing the distribution of error in recalling information, providing new insights into the organization of the WM system. Hence, by utilizing two continuous reproduction paradigms, memory-guided localization (MGL) and analog recall task with sequential presentation, we investigated WM dysfunction in MS.

SUBMITTER: Motahharynia A 

PROVIDER: S-EPMC10631758 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature